Abstract
IT has been pointed out1 that a low activity of hepatic pyruvate kinase (ATP-phosphotransferase EC.2.7.1.40) favours gluconeogenesis, and a high activity favours lipogenesis from oxidizable substances. These experiments with rats showed that the activity of the enzyme was rapidly affected by alterations the amount of carbohydrate in the diet, being highest when the diet contained 55 percent carbohydrate (mostly as starch) and least when it contained no carbohydrate.
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References
Krebs, H. A., and Eggleston, L. V., Biochem. J., 94, 3c (1965).
Al-Nagdy, S., Miller, D. S., Qureshi, R. U., and Yudkin, J., Nature, 209, 81 (1966).
Bücher, T., and Pfleiderer, G., in Methods in Enzymology (edit. by Colowick, S. P., and Kaplan, N. O.), 1, 435 (Academic Press, New York, 1955).
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YUDKIN, J., KRAUSS, R. Dietary Starch, Dietary Sucrose and Hepatic Pyruvate Kinase in Rat. Nature 215, 75 (1967). https://doi.org/10.1038/215075a0
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DOI: https://doi.org/10.1038/215075a0
