Abstract
PROGESTERONE has been found to be an effective anaesthetic agent when given intraperitoneally to animals1,2 and 21 hydroxy pregnandione succinate has been used clinically for general anaesthesia3. Of practical importance in clinical anaesthesia is the fact that in animals progesterone potentiated the effect of ether and chloroform2. No clinical confirmation of this effect in humans is, however, available. Paradoxically, it is believed that progesterone renders the respiratory centre more sensitive to carbon dioxide and that this may account for the lowered pCO2 in blood during pregnancy.
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References
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LURIE, A., WEISS, J. Progesterone in Cerebrospinal Fluid during Human Pregnancy. Nature 215, 1178 (1967). https://doi.org/10.1038/2151178a0
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DOI: https://doi.org/10.1038/2151178a0
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