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Effect of Route of Administration on Immuno-suppression by DMBA in CBA Mice

Nature volume 215, pages 1497–1498 (1967)Cite this article

Abstract

IT has been known for some time that certain chemical carcinogens depress the immune response1. When the carcinogen is given neonatally this depression may be long lasting2. Stjernswärd has shown that in addition to depressing the serum haemolysin response to heterologous red cells, a number of carcinogens lower the number of antibody forming cells in the spleen as measured by the Jerné technique3. No such depression was found in response to non-carcinogenic analogues tested, but whether or not immunological impairment is an integral part of carcinogenesis as suggested by Prehn and Main4 is not yet known. Tumour-specific antigens have been demonstrated in a variety of chemically induced tumours of both mesodermal and epidermal origin5,6. Transformed cells multiplying to form macroscopically recognizable tumours seem to do so despite their antigenicity : they may represent only the proportion of potentially neoplastic cells which have in some way overcome host resistance.

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Authors and Affiliations

  1. Chester Beatty Research Institute, Institute of Cancer Research : Royal Cancer Hospital, London

    B. J. WESTON

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  1. B. J. WESTON
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WESTON, B. Effect of Route of Administration on Immuno-suppression by DMBA in CBA Mice. Nature 215, 1497–1498 (1967). https://doi.org/10.1038/2151497a0

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