Abstract
IT is well known that after immunological stimulation, animals produce non-specific gamma globulins as well as specific antibody1. Quantitative studies have shown that injection into guinea-pigs of an antigen mixed with Freund's adjuvant causes a marked increase in the serum concentrations of γ1 and γ2 globulins, only part of which can precipitate with the antigen2. On the other hand, the induction of immune paralysis in adult guinea-pigs is accompanied by a transient immunological unresponsiveness to unrelated antigens3. A possible explanation for this phenomenon could be that immunological paralysis may start by a defective commitment of immunologically competent cells, which does not result in the production of specific antibody. The aim of the present work was to find out whether the induction of paralysis also results in an increase of γ1 and γ2 globulins which might account for some kind of commitment of the competent cells.
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LIACOPOULOS, P., PERRAMANT, M. & BINAGHI, R. Increased IgG Synthesis during the Induction of Immunological Paralysis in Adult Guinea-pigs. Nature 216, 81–82 (1967). https://doi.org/10.1038/216081a0
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DOI: https://doi.org/10.1038/216081a0
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