Abstract
ERYTHROCYTES from patients with paroxysmal nocturnal haemoglobinuria (PNH) are lysed excessively by agents which peroxidize lipid, and their lipid forms more lipid peroxides than that of normal erythrocytes1,2. Recently we noted that incubation of normal red blood cells in reduced glutathione results in cells with all the usual in vitro lytic features of “natural” PNH cells. In the work reported here we have compared lipid extracts from red blood cells of normal subjects and patients with various haemolytic disorders with those of “natural” and “induced” PNH cells, with respect to peroxidation.
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References
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MERIWETHER, W., MENGEL, C. Peroxidation of Lipid from Paroxysmal Nocturnal Haemoglobinuria-like Erythrocytes. Nature 216, 85–86 (1967). https://doi.org/10.1038/216085a0
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DOI: https://doi.org/10.1038/216085a0
