Abstract
MANY compounds are specific inhibitors of protein synthesis and the mechanism of their action has been much investigated. Not all compounds which inhibit protein synthesis in micro-organisms do so in ribosomal systems of mammalian origin, for example, chloramphenicol1–3. In yeasts an interesting dichotomy has been described between materials inhibiting mitochondrial but not ribosomal systems, for example, tetracycline and macrolides, and vice versa, for example, cycloheximide4.
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References
Borsook, H., Fischer, E. H., and Keighley, G., J. Biol. Chem., 229, 1059 (1957).
Von Ehrenstein, G., and Lipmann, F., Proc. US Nat. Acad. Sci., 47, 941 (1961).
Allen, E. H., and Schweet, R. S., J. Biol. Chem., 237, 760 (1962).
Clark-Walker, G. D., and Linnane, A. W., Biochem. Biophys. Res. Commun., 25, 8 (1966).
Von Der Decken, A., in Techniques in Protein Biosynthesis (edit. by Campbell, P. N., and Sargent, J. R.), 65 (Academic Press, 1967).
Breuer, C. B., Davies, M. C., and Florini, J. R., Biochemistry, 3, 1713 (1964).
Earl, D. C. N., and Korner, A., Biochem. J., 94, 721 (1965).
Florini, J. R., Biochemistry, 3, 209 (1964).
Florini, J. R., and Breuer, C. B., Biochemistry, 4, 253 (1965).
Kalf, G. F., Arch. Biochem. Biophys., 101, 350 (1963).
Kroon, A. M., Biochim. Biophys. Acta, 72, 391 (1963).
Manchester, K. L., Biochem. J., 98, 711 (1966).
Manchester, K. L., Biochem. J., 81, 135 (1961).
Manchester, K. L., and Young, F. G., Biochem. J., 75, 487 (1960).
Wool, I. G., Castles, J. J., and Moyer, A. N., Biochim. Biophys. Acta, 107, 333 (1965).
Manchester, K. L., Biochem. J., 90, 5C (1964).
Wool, I. G., and Moyer, A. N., Biochim. Biophys. Acta, 91, 248 (1964).
Manchester, K. L., and Young, F. G., J. Endocrinol., 18, 381 (1959).
Truman, D. E. S., and Löw, H., Exp. Cell Res., 31, 230 (1963).
Weisberger, A. S., Armentrout, S., and Wolfe, S., Proc. US Nat. Acad. Sci., 50, 86 (1963).
Barnabei, O., and Sereni, F., Biochim. Biophys. Acta, 91, 239 (1964).
Farese, R. V., Biochim. Biophys. Acta, 87, 699 (1964).
Godchaux, W., and Herbert, E., J. Mol. Biol., 21, 537 (1967).
Eboué-Bonis, D., Chambaut, A. M., Volfin, P., and Clauser, H., Nature, 199, 1183 (1963).
Elsas, L. J., Albrecht, I., Koehne, W., and Rosenberg, L. E., Nature, 214, 916 (1967).
Castles, J. J., and Wool, I. G., Biochem. J., 91, 11C (1964).
Wool, I. G., and Cavicchi, P., Proc. US Nat. Acad. Sci., 56, 991 (1966).
Garren, L. D., Ney, R. L., and Davis, W. W., Proc. US Nat. Acad. Sci., 53, 1443 (1965).
Korner, A., Biochem. J., 101, 627 (1966).
Trakatellis, A. C., Montjar, M., and Axelrod, A. E., Biochemistry, 4, 2065 (1965).
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MANCHESTER, K. Effects of Antibiotics on Protein Synthesis in Muscle and Implications with regard to the Action of Insulin. Nature 216, 394–395 (1967). https://doi.org/10.1038/216394a0
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DOI: https://doi.org/10.1038/216394a0
