Abstract
WHOLE rabbit brains were homogenized in 0.32 molar sucrose solution, and subcellular fractions were prepared by centrifugation by the method of Gray and Whittaker1. Prostaglandins were extracted from the homogenates and from the various fractions by solvent partition and further purified by chromatography2.
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References
Gray, E. G., and Whittaker, V. P., J. Anat., 96, 79 (1962).
Horton, E. W., and Main, I. H. M., Brit. J. Pharmacol. Chemother., 30, 582 (1967).
Ambache, N., Brummer, H. C., Rose, J. G., and Whiting, J., J. Physiol., 185, 77 (1966).
Wolfe, L. S., Coceani, F., and Pace-Asciak, C., Proc. Second Nobel Symposium on Prostaglandins (Almqvist and Wicksell, Uppsala, 1967).
Kataoka, K., Ramwell, P. W., and Jessup, S., Science, 157, 1187 (1967).
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HOPKIN, J., HORTON, E. & WHITTAKER, V. Prostaglandin Content of Particulate and Supernatant Fractions of Rabbit Brain Homogenates. Nature 217, 71–72 (1968). https://doi.org/10.1038/217071a0
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DOI: https://doi.org/10.1038/217071a0
