Abstract
TREATMENT of hyperuricaemia and gout is aimed at either synthesis or elimination of uric acid. Previous attempts at in situ destruction of uric acid have remained experimental because of imperfections in the enzymes. The therapeutic use of a new uricase or urate oxidase derived from Aspergillus flavus has been studied.
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KISSEL, P., LAMARCHE, M. & ROYER, R. Modification of Uricaemia and the Excretion of Uric Acid Nitrogen by an Enzyme of Fungal Origin. Nature 217, 72–74 (1968). https://doi.org/10.1038/217072a0
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DOI: https://doi.org/10.1038/217072a0
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