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Nuclear Uptake of Exogenous DNA by Mammalian Cells in Culture

Abstract

The uptake of exogenous DNA by mammalian cells in culture may amount to 5 per cent of the host cell complement. This material is found within the nucleus, but most of it is not incorporated into the chromosomes.

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References

  1. Ledoux, L., Prog. Nucleic Acid Res., 4, 231 (1965).

    Article  CAS  Google Scholar 

  2. Wilczok, T., and Mendeki, J., Intern. J. Radiat. Biol., 9, 201 (1965).

    CAS  Google Scholar 

  3. Petrovic, D., Miletic, B., Ferle-Vidovic, A., and Han, A., Radiat. Res., 27, 41 (1966).

    Article  ADS  CAS  Google Scholar 

  4. Savkovic, N., Kacaki, J., and Hajdnukovic, S., Nature, 211, 1179 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Horikawa, M., Sagahara, T., and Doida, Y., Exp. Cell Res., 34, 198 (1964).

    Article  CAS  PubMed  Google Scholar 

  6. Cantarow, A., Williams, T. L., and Goddard, J. W., Cancer Res., 26, 652 (1966).

    PubMed  CAS  Google Scholar 

  7. Glick, J. L., and Goldberg, A. R., Trans. NY Acad. Sci., 28, 741 (1966).

    Article  CAS  Google Scholar 

  8. Bendich, A., Wilczok, T., and Borenfreund, E., Science, 148, 374 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Fischer, G. A., Methods in Medical Research, 10, 247 (1964).

    PubMed  CAS  Google Scholar 

  10. Meizel, S., and Kay, E. R. M., Biochem. Biophys. Acta, 103, 431 (1965).

    PubMed  CAS  Google Scholar 

  11. Creasey, W. A., and Stocken, L. A., Biochem. J., 72, 519 (1959).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ledoux, L., Gerber, G. B., Charles, P., Remy, J., and Remy-Defraigue, J., Experientia, 23, 16 (1967).

    Article  CAS  PubMed  Google Scholar 

  13. Ledoux, L., and Huart, R., Biochim. Biophys. Acta, 134, 209 (1967).

    Article  CAS  Google Scholar 

  14. Ledoux, L., Charles, P., and Srögl, M., Nature, 214, 1241 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Ledoux, L., and Charles, P., Arch. Intern. Physiol. et Biochim., 75, 363 (1967).

    CAS  Google Scholar 

  16. Robins, A. B., Nature, 215, 1291 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Bond, P. S., J. Chromatog. (in the press).

Download references

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ROBINS, A., TAYLOR, D. Nuclear Uptake of Exogenous DNA by Mammalian Cells in Culture. Nature 217, 1228–1231 (1968). https://doi.org/10.1038/2171228a0

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