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Urinary Hydroxyproline Excretion in Phosphate Depleted Rachitic Rats

Nature volume 217, pages 551–552 (1968)Cite this article

Abstract

THE increased output of hydroxyproline peptides in the urine of patients with osteomalacia1 has been found to increase still further when the rickets are cured with phosphate2. Studies using 14C-proline indicate that the hydroxyproline in the urine of growing rats is derived both from recently synthesized soluble collagen and from the catabolism of the mature insoluble collagen fibres3. The experiments reported here were designed to discover whether the increased excretion of hydroxyproline in healing rickets comes from the synthesis of new collagen.

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Authors and Affiliations

  1. Department of Medicine, King's College Hospital, London

    VICTOR PARSONS & MALCOLM SELF

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  1. VICTOR PARSONS
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  2. MALCOLM SELF
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PARSONS, V., SELF, M. Urinary Hydroxyproline Excretion in Phosphate Depleted Rachitic Rats. Nature 217, 551–552 (1968). https://doi.org/10.1038/217551a0

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