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Competitive Binding of Streptomycin and Magnesium with Escherichia coli Ribosomes

Nature volume 217, pages 556–557 (1968)Cite this article

Abstract

SEVERAL laboratories have presented evidence that streptomycin inhibits protein synthesis of sensitive bacteria1–4. Studies with cell free systems have clearly shown that the 30S sub-unit of the ribosomes derived from streptomycin-sensitive cells is the site of action of this antibiotic5–8. It has also been shown that one to two molecules of streptomycin bound to one ribosome particle suffice to exert an inhibitory effect on polypeptide synthesis9,10.

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Authors and Affiliations

  1. Department of Biochemistry, University of Minnesota, Minneapolis, Minnesota

    YONG SUNG CHOI & CHARLES W. CARR

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  1. YONG SUNG CHOI
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  2. CHARLES W. CARR
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CHOI, Y., CARR, C. Competitive Binding of Streptomycin and Magnesium with Escherichia coli Ribosomes. Nature 217, 556–557 (1968). https://doi.org/10.1038/217556a0

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