Abstract
IN adult mammals the epidermal cell population is in a steady state—continuous cell loss by keratinization is balanced quantitatively by new cell production in the basal layer. We have found that the turnover time of albino guinea-pig epidermis (time required for the replacement of a number of cells equal to that present in the basal, spinous and granular layers) differed from that reported by Platt1 and also from that found for other mammals 2–5.
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References
Platt, H., Nature, 184, 1654 (1959).
Epstein, W. L., and Maibach, H. I., Arch. Dermatol., 92, 462 (1965).
Weinstein, G. D., and Van Scott, E. J., J. Invest. Dermatol., 45, 257 (1965).
Weinstein, G. D., J. Invest. Dermatol., 44, 413 (1965).
Sherman, F. G., Quastler, H., and Wimber, D. R., Exp. Cell Res., 25, 114 (1961).
Leblond, C. P., Greulich, R. C., and Pereira, J. P. M., Symp. on Wound Healing (edit. by Montagna, W.), 39 (Pergamon Press, New York, 1964).
Epstein, jun., E. H., and Epstein, W. L., J. Invest. Dermatol., 46, 453 (1966).
Bertalanffy, F. D., Lab. Invest., 13, 871 (1964).
Baserga, R., and Nemeroff, K., J. Histochem. Cytochem., 10, 628 (1962).
Wimber, D. E., Symp. on Cell Proliferation (edit. by Lamerton, L. F., and Fry, R. J. M.), 1 (F. A. Davis Co., Philadelphia, 1963).
Pederson, T., and Gelfant, S., Seventh Ann. Meeting Amer. Soc. Cell Biol., Denver, Colorado, Abstract No. 209 (1967).
Skjaeggestad, O., Acta Pathol. Microbiol. Scand., Suppl. 169 (1964).
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SONG, C., TABACHNICK, J. Epidermal Cell Population Kinetics in Albino Guinea-pig Skin. Nature 217, 650–651 (1968). https://doi.org/10.1038/217650a0
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DOI: https://doi.org/10.1038/217650a0
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