Abstract
RED blood cells, onto which various unrelated antigens have been adsorbed or coupled chemically, may become sensitized to lysis by antibody against the adsorbed antigen in the presence of complement1. In other words, lysis of red cells in this manner results from a heterologous antigen–antibody reaction with fixation of complement occurring on its surface. The component requirements for cell damage by this system of antibody and complement seem to be identical irrespective of the nature of the cell involved, whether it is a red cell, a tissue cell or a Gram negative bacterium. Passive sensitization to complement-induced lysis has been achieved using red cells coated with lipopolysaccharides or with bovine serum albumin (BSA)2, with mast cells3–5 and with lymphocytes6,7 among others.
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ROWLEY, D., TURNER, K. Passive Sensitization of Salmonella adelaide to the Bactericidal Action of Antibody and Complement. Nature 217, 657–658 (1968). https://doi.org/10.1038/217657a0
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DOI: https://doi.org/10.1038/217657a0
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