Abstract
BLOOD plasma and serum contain a heat labile substance which alters endotoxin so that it no longer elicits many of its characteristic effects on the host responses. Endotoxin incubated in vitro with human or other animal sera no longer sensitized, for the local Shwartzman reaction produced vasomotor collapse in rabbits or elicited dermal haemorrhage and necrosis in rabbits treated with adrenaline1. Treatment with serum also reduced the tumour necrotizing activity of endotoxin in mice1 and reduced or abolished the pyrogenicity of endotoxin2. Serum or plasma also lowered the lethality for rats of crude endotoxin containing extracts from S. typhosa3.
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FUKUI, G., GOLDENBAUM, E. & BERGER, F. Effect of Plasma on Non-specific Resistance to Infection induced by Endotoxin or Protodyne. Nature 218, 362–363 (1968). https://doi.org/10.1038/218362a0
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DOI: https://doi.org/10.1038/218362a0
