Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Effects of Anti-thymocyte Serum on Rauscher Virus Infection of Mice

Nature volume 218, pages 478–479 (1968)Cite this article

Abstract

CELL-MEDIATED immune responses seem to be the principal host defence against virus-induced tumours and leukaemias1. Transfer of sensitized lymphoid cells can produce resistance to tumour induction or transplantation, whereas depression of cell-mediated immune mechanisms results in enhanced susceptibility to viral oncogenesis or leukaemogenesis2. The most potent suppressants of cellular immunity yet described are anti-lymphoid sera3. These sera have been used primarily to suppress homograft rejection after tissue transplantation, but have also been used to investigate mechanisms of viral pathogenesis. They have been found to potentiate polyoma and adenovirus oncogenesis4,5, as well as Moloney virus leukaemogenesis5, whereas they delay or prevent signs of lyinphocytic choriomeningitis (LCM) and yellow fever infections6–9. We report an examination of the effects of rabbit anti-mouse thymocyte (RAMT) serum on the development of Rauscher leukaemia virus infection.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Allison, A. C., Brit. Med. Bull., 23, 60 (1967).

    Article  CAS  Google Scholar 

  2. Allison, A. C., and Taylor, R. B., Cancer Res., 27, 703 (1967).

    CAS  PubMed  Google Scholar 

  3. Levey, R. H., and Medawar, P. B., Proc. US Nat. Acad. Sci., 56, 1130 (1966).

    Article  ADS  CAS  Google Scholar 

  4. Allison, A. C., Berman, L. D., and Levey, R. H., Nature, 215, 185 (1967).

    Article  ADS  CAS  Google Scholar 

  5. Allison, A. C., and Law, L. W., Proc. Soc. Exp. Biol. and Med., 127, 207 (1968).

    Article  CAS  Google Scholar 

  6. Gledhill, A. W., Nature, 214, 178 (1967).

    Article  ADS  CAS  Google Scholar 

  7. Hirsch, M. S., Murphy, F. A., Russe, H. P., and Hicklin, M. D., Proc. Soc. Exp. Biol. and Med., 125, 980 (1967).

    Article  CAS  Google Scholar 

  8. Hirsch, M. S., and Murphy, F. A., Nature, 216, 179 (1967).

    Article  ADS  CAS  Google Scholar 

  9. Hirsch, M. S., Murphy, F. A., and Hicklin, M. D., J. Exp. Med., 127, 757 (1968).

    Article  CAS  Google Scholar 

  10. Rauscher, F. J., J. Nat. Cancer Inst., 29, 515 (1962).

    CAS  PubMed  Google Scholar 

  11. Rauscher, F. J., and Allen, B. V., J. Nat. Cancer Inst., 32, 269 (1964).

    CAS  PubMed  Google Scholar 

  12. Chirigos, M. A., Ann. NY Acad. Sci., 130, 56 (1965).

    Article  ADS  CAS  Google Scholar 

  13. James, K., Clin. Exp. Immunol., 2, 615 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Gray, J. G., Monaco, A. P., Wood, M. L., and Russell, P. S., J. Immunol., 96, 217 (1966).

    CAS  PubMed  Google Scholar 

  15. Russe, H. P., and Crowle, A. J., J. Immunol., 94, 74 (1965).

    CAS  PubMed  Google Scholar 

  16. Volkert, M., and Lunstedt, C., J. Exp. Med., 121, 327 (1968).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Health, Education and Welfare, US Public Health Service, National Communicable Disease Center, Atlanta, Georgia

    M. S. HIRSCH & F. A. MURPHY

Authors
  1. M. S. HIRSCH
    View author publications

    Search author on:PubMed Google Scholar

  2. F. A. MURPHY
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

HIRSCH, M., MURPHY, F. Effects of Anti-thymocyte Serum on Rauscher Virus Infection of Mice. Nature 218, 478–479 (1968). https://doi.org/10.1038/218478a0

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/218478a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing