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Mechanism of Lymphocyte Transformation induced by Phytohaemagglutinin

Nature volume 219, pages 1021–1025 (1968)Cite this article

Abstract

The role of phytohaemagglutinin (PHA) determinants and lymphocyte surface reactive sites has been investigated in the lymphocyte transformation phenomenon. Results suggest that the mitogenic moiety of the PHA molecule is closely related to or identical with the antigenic determinant sites, and that some of these PHA antigenic sites are similar to those found amongst the antigenic configuration on the surface of lymphocytes.

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Authors and Affiliations

  1. Immunology Section, Surgical Research Department, Royal Children's Hospital Research Foundation,

    M. J. SIMONS & R. FOWLER

  2. Cytogenetics Laboratory, Department of Pathology, Royal Children's Hospital, Melbourne, Australia

    M. G. FITZGERALD

Authors
  1. M. J. SIMONS
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  2. R. FOWLER
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  3. M. G. FITZGERALD
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SIMONS, M., FOWLER, R. & FITZGERALD, M. Mechanism of Lymphocyte Transformation induced by Phytohaemagglutinin. Nature 219, 1021–1025 (1968). https://doi.org/10.1038/2191021a0

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  • DOI: https://doi.org/10.1038/2191021a0

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