Abstract
SUTHERLAND and his collaborators have firmly established that the cyclic nucleotide, adenosine 3′,5′-monophosphate (CAMP), is a ubiquitous regulator of a variety of intracellular processes1. Its role in the activation of phosphorylase has been elucidated by Sutherland and Rall2. It is now almost certain that CAMP also participates in the activation of lipase in adipose tissue3, and may affect the activity of such key regulator enzymes as phosphofructokinase4,5. Furthermore, CAMP has been implicated as the intracellular mediator of a variety of hormonal effects ranging from steroidogenesis in the corpus luteum and adrenal cortex to increased water permeability in toad bladder and kidney tubules1.
Similar content being viewed by others
Article PDF
References
Sutherland, E. W., and Robison, G. A., Pharm. Revs., 18, 145 (1966).
Sutherland, E. W., and Rall, T. W., J. Biol. Chem., 232, 1077 (1958).
Butcher, R. W., Ho, R. J., Meng, H. C., and Sutherland, E. W., J. Biol. Chem., 240, 4515 (1965).
Mansour, T. E., and Mansour, J. M., J. Biol. Chem., 237, 629 (1962).
Denton, R. M., and Randle, P. J., Biochem. J., 100, 240 (1966).
Butcher, R. W., and Sutherland, E. W., J. Biol. Chem., 237, 1244 (1962).
Weiland, O., Biochem. Z., 329, 313 (1957).
Posternak, T., Sutherland, E. W., and Henion, W. F., Biochim. Biophys. Acta, 65, 558 (1962).
Douglas, W. W., in the Pharmacological Basis of Therapeutics (edit. by Goodman, L. S., and Gilman, A.), 615 (Macmillan, New York, 1965).
Stock, K., and Westermann, E., Life Sci., 5, 1667 (1966).
Bergman, R. K., and Munoz, J., Nature, 217, 174 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GOODMAN, H. Proposed Mode of Action of Histamine. Nature 219, 1053 (1968). https://doi.org/10.1038/2191053a0
Received:
Revised:
Issue date:
DOI: https://doi.org/10.1038/2191053a0
This article is cited by
-
Fluorimetric determination of histamine and serotonin in mast cells of normal and germfree rats treated with reserpine and cyclic AMP
Bulletin of Experimental Biology and Medicine (1977)
