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Delayed Death in Rats treated with Cyclophosphamide

Nature volume 219, pages 1154–1155 (1968)Cite this article

Abstract

IN a study of the therapeutic effect of cyclophosphamide on an SV 40 sarcoma in rat (ref. 1 and unpublished results of U. Stenram, E. Nilsson and R. Berg), we found that many of the treated rats died without tumour after about 2 months. This phenomenon seems to have been very little discussed in the literature, and so we began an investigation. This is our first report.

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References

  1. Stenram, U., Nilsson, E., and Berg, R., Acta Pathol. Microbiol. Scand., 72, 452 (1968).

    CAS  PubMed  Google Scholar 

  2. Brock, N., Arzneimittelforschung, 8, 1 (1958).

    CAS  PubMed  Google Scholar 

  3. Larionov, L. F., Cancer Chemotherapy (Pergamon Press, London, 1965).

    Google Scholar 

  4. Philips, F., Sternberg, S., Cronin, A., and Vidal, P., Cancer Res., 21, 1577 (1961).

    CAS  PubMed  Google Scholar 

  5. Skipper, H., and Schmidt, L., Cancer Chemother. Rep., 17, 1 (1962).

    CAS  PubMed  Google Scholar 

  6. Schmidt, L. H., Fradkin, R., Sullivan, R., and Flowers, A., Cancer Chemother. Rep., Suppl. 2, 1 (1965).

  7. Miller, E., and Tsou, K. C., Proc. Amer. Assoc. Cancer Res., 7, 50 (1966).

    Google Scholar 

  8. Wheeler, A. G., Dansby, D., Hawkins, H. C., Payne, H. G., and Weikel, jun., J. H., Toxicol. Appl. Pharmacol., 4, 324 (1962).

    Article  CAS  PubMed  Google Scholar 

  9. Elson, L. A., Experimental Chemotherapy (edit. by Schnitzer, R. J., and Hawking, F.), V, Part II, 417 (Academic Press, New York, 1967).

    Google Scholar 

  10. Ekstedt, R., and Hayes, L., J. Immunol., 98, 110 (1967).

    CAS  PubMed  Google Scholar 

  11. Stanley, N. F., and Walters, N.-I. M., Lancet, i, 962 (1966).

  12. Joske, R. A., Leak, P. J., Papadimitriou, J. M., Stanley, N. F., and Walters, M. N. -I., Brit. J. Exp. Pathol., 47, 337 (1966).

    CAS  Google Scholar 

  13. Rutman, R. J., in Wilmanns, H., Chemotherapie Maligner Tumoren, 151 (Schattauer Verlag, Stuttgart, 1964).

    Google Scholar 

  14. Röhrborn, G., in Wilmanns, H., Chemotherapie Maligner Tumoren, 183 (Schattauer Verlag, Stuttgart, 1964).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pathology, University of Uppsala, Uppsala, Sweden

    UNNE STENRAM & HANS NORDLINDER

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  1. UNNE STENRAM
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  2. HANS NORDLINDER
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STENRAM, U., NORDLINDER, H. Delayed Death in Rats treated with Cyclophosphamide. Nature 219, 1154–1155 (1968). https://doi.org/10.1038/2191154a0

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