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Polymorphism in Collagen Fibrils precipitated at Low pH

Nature volume 219, pages 1279–1280 (1968)Cite this article

Abstract

THE reconstitution of collagen molecules to give native fibrils has been investigated with a view to explaining the 640 A periodicity1,2 and also to account for the overall shape3,4. Reconstitution has usually been carried out in vitro by increasing the pH of an acid solution of tropocollagen molecules to neutrality in the presence of various ions and macromolecules, thus precipitating out fibrils—see Wood's review5. In the work reported here, crystallization was carried out at a pH near the solubility limit in order to obtain further information about the precipitation process.

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Authors and Affiliations

  1. Rheumatism Research Centre, University of Manchester,

    JONATHAN B. L. BARD & JOHN A. CHAPMAN

Authors
  1. JONATHAN B. L. BARD
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  2. JOHN A. CHAPMAN
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BARD, J., CHAPMAN, J. Polymorphism in Collagen Fibrils precipitated at Low pH. Nature 219, 1279–1280 (1968). https://doi.org/10.1038/2191279a0

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