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Binding of Formylmethionyl-tRNA and Aminoacyl-tRNA to Ribosomes

Nature volume 219, pages 238–243 (1968)Cite this article

Abstract

Inhibition of aminoacyl-tRNA binding by the purified initiation factors f1 and f2 could be regarded as a mechanism for ensuring that only F-met-tRNA binds initially to the entry site, thereby preventing random or non-specific binding by aminoacyl-tRNA. This inhibition would be relieved by the hydrolysis of the GTP molecule normally involved in the binding of F-met-tRNA.

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Authors and Affiliations

  1. Department of Chemistry and Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts

    TAKAHISA OHTA & ROBERT E. THACH

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  1. TAKAHISA OHTA
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  2. ROBERT E. THACH
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OHTA, T., THACH, R. Binding of Formylmethionyl-tRNA and Aminoacyl-tRNA to Ribosomes. Nature 219, 238–243 (1968). https://doi.org/10.1038/219238a0

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