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Factors controlling the Interconversion of Enzyme–Substrate Compounds of Pig Heart Lactate Dehydrogenase

Abstract

Stopped flow and temperature jump experiments make possible a description of the individual catalytic steps. Detailed results favour the induced fit hypothesis of enzyme action.

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References

  1. Schwert, G. W., Miller, B. R., and Peanasky, R. J., J. Biol. Chem., 242, 3245 (1967).

    PubMed  CAS  Google Scholar 

  2. Heck, H. d'A., McMurray, C. H., and Gutfreund, H., Biochem. J., 108, 793 (1968).

    Article  CAS  Google Scholar 

  3. Gutfreund, H., Cantwell, R., McMurray, C. H., Criddle, R. S., and Hathaway, G., Biochem. J., 106, 683 (1968).

    Article  CAS  Google Scholar 

  4. Hathaway, G., and Criddle, R. S., Proc. US Nat. Acad. Sci., 56, 680 (1966).

    Article  ADS  CAS  Google Scholar 

  5. Eigen, M., Quart. Rev. Biophys., 1, 3 (1968).

    Article  CAS  Google Scholar 

  6. Bernhard, S. A., The Structure and Function of Enzymes, 248 (Benjamin, New York, 1968).

    Google Scholar 

  7. Monod, J., Wyman, J., and Changeux, P., J. Mol. Biol., 12, 88 (1965).

    Article  CAS  Google Scholar 

  8. Trentham, D. R., and Gutfreund, H., Biochem. J., 106, 455 (1968).

    Article  CAS  Google Scholar 

  9. Koshland, D. E., Proc. US Nat. Acad. Sci., 44, 98 (1958).

    Article  ADS  CAS  Google Scholar 

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CRIDDLE, R., McMURRAY, C. & GUTFREUND, H. Factors controlling the Interconversion of Enzyme–Substrate Compounds of Pig Heart Lactate Dehydrogenase. Nature 220, 1091–1095 (1968). https://doi.org/10.1038/2201091a0

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