Abstract
A GENETICALLY determined heterogeneity (doubling) of the human complement component C′3, which can be detected by agar gel electrophoresis, has been described in two unrelated families of Flemish stock in Belgium1,2. The frequency of this anomaly seems to be extremely low and no clear relationship with a diseased state has been detected. A similar anomaly which does not seem to be genetically determined has also been described3–5. The frequency of this anomaly is somewhat greater than the other and its occurrence has been correlated with the presence of neoplastic disease6.
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References
Wieme, R. J., and Demeulenaere, L., Nature, 214, 1042 (1967).
Wieme, R. J., Demeulenaere, L., and Segers, J., Prot. Biol. Fluids (Proc. Fifteenth Colloq., Bruges), 15, 499 (Elsevier, Amsterdam, 1968).
Wieme, R. J., Studies on Agar Electrophoresis, thesis, 321 (Arscia, Brussels, 1959).
Wieme, R. J., Agar Gel Electrophoresis, 238 (Elsevier, Amsterdam, 1965).
Alper, C. A., and Propp, R. P., Clin. Res., 15, 291 (1967).
Wieme, R. J., Acta Clinica Belg. (in the press).
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WIEME, R., SEGERS, J. Genetic Polymorphism of the Complement Component C′3 in a Bantu Population. Nature 220, 176 (1968). https://doi.org/10.1038/220176a0
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DOI: https://doi.org/10.1038/220176a0
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