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Effects of Cerebral Stimulation on the Biosynthesis in vitro of Nucleotides and RNA in Brain

Nature volume 221, page 1053 (1969)Cite this article

Abstract

IN view of the possibility that memory, such as that acquired in learning, is represented by some permanent change in the brain, and that the change is brought about as a result of chemical activity in the brain cell, we carried out experiments to observe whether various stimulating agents affect nucleotide and RNA biosynthesis in isolated brain. We examined the effects of electrical stimulation, and of changes in the cation composition of the incubation medium and of acetylcholine, on the rates of incorporation of labelled uridine into uridine nucleotides and RNA in slices of rat brain cortex. The results are summarized here. Full details will be published elsewhere.

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Author notes

  1. CAROL PRIVES

    Present address: Department of Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461

Authors and Affiliations

  1. Neurochemistry Section, Kinsmen Laboratories, University of British Columbia, Vancouver, 8

    CAROL PRIVES & J. H. QUASTEL

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  1. CAROL PRIVES
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  2. J. H. QUASTEL
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PRIVES, C., QUASTEL, J. Effects of Cerebral Stimulation on the Biosynthesis in vitro of Nucleotides and RNA in Brain. Nature 221, 1053 (1969). https://doi.org/10.1038/2211053a0

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  • DOI: https://doi.org/10.1038/2211053a0

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