Abstract
RECENT evidence suggests that protein synthesis is necessary before vitamin D can affect Ca transport in the intestine. Thus the vitamin D-stimulated absorption of Ca is inhibited by actinomycin D (ref. 1), and further, the vitamin increases the incorporation in the intestine of orotic acid into nuclear RNA (ref. 2 and unpublished results of D. E. M. L., P. W. W., E. K., and D. C. Barker).
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References
Eisenstein, R., and Passavoy, M., Proc. Soc. Exp. Biol. and Med., 117, 77 (1964).
Stohs, S. J., and DeLuca, H. F., Biochemistry, 6, 3338 (1967).
Haussler, M. R., and Norman, A. W., Arch. Biochem. Biophys., 118, 145 (1967).
Blunt, J. W., DeLuca, H. F., and Schnoes, H. K., Biochemistry, 7, 3317 (1968).
Morii, H., Lund, J., Neville, P. F., and DeLuca, H. F., Arch. Biochem. Biophys., 120, 508 (1967).
Bligh, E. G., and Dyer, W. J., Canad. J. Biochem. Physiol., 37, 911 (1959).
Haussler, M. R., Myrtle, J. F., and Norman, A. W., J. Biol. Chem., 243, 4055 (1968).
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LAWSON, D., WILSON, P. & KODICEK, E. New Vitamin D Metabolite localized in Intestinal Cell Nuclei. Nature 222, 171–172 (1969). https://doi.org/10.1038/222171a0
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DOI: https://doi.org/10.1038/222171a0
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