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New Vitamin D Metabolite localized in Intestinal Cell Nuclei

Abstract

RECENT evidence suggests that protein synthesis is necessary before vitamin D can affect Ca transport in the intestine. Thus the vitamin D-stimulated absorption of Ca is inhibited by actinomycin D (ref. 1), and further, the vitamin increases the incorporation in the intestine of orotic acid into nuclear RNA (ref. 2 and unpublished results of D. E. M. L., P. W. W., E. K., and D. C. Barker).

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References

  1. Eisenstein, R., and Passavoy, M., Proc. Soc. Exp. Biol. and Med., 117, 77 (1964).

    Article  CAS  Google Scholar 

  2. Stohs, S. J., and DeLuca, H. F., Biochemistry, 6, 3338 (1967).

    Article  CAS  Google Scholar 

  3. Haussler, M. R., and Norman, A. W., Arch. Biochem. Biophys., 118, 145 (1967).

    Article  CAS  Google Scholar 

  4. Blunt, J. W., DeLuca, H. F., and Schnoes, H. K., Biochemistry, 7, 3317 (1968).

    Article  CAS  Google Scholar 

  5. Morii, H., Lund, J., Neville, P. F., and DeLuca, H. F., Arch. Biochem. Biophys., 120, 508 (1967).

    Article  CAS  Google Scholar 

  6. Bligh, E. G., and Dyer, W. J., Canad. J. Biochem. Physiol., 37, 911 (1959).

    Article  CAS  Google Scholar 

  7. Haussler, M. R., Myrtle, J. F., and Norman, A. W., J. Biol. Chem., 243, 4055 (1968).

    PubMed  CAS  Google Scholar 

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LAWSON, D., WILSON, P. & KODICEK, E. New Vitamin D Metabolite localized in Intestinal Cell Nuclei. Nature 222, 171–172 (1969). https://doi.org/10.1038/222171a0

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