Abstract
THE lysosomal system probably plays a key part in the resorption of articular and connective tissues, both in physiological remodelling and during pathological damage1–4. The hypothesis5–7 that lysosomal cathepsin D is primarily responsible for the extracellular and intracellular degradation of the organic matrix of skeletal tissues has been based on strong but circumstantial evidence, and other workers have proposed the involvement of hyaluronidase, cathepsin B and β-xylosidase (reviewed by Barrett8). If the hypothesis that cathepsin D is the enzyme primarily responsible proves to be correct, it has important implications in the pathology of connective tissue disease, particularly rheumatoid arthritis9.
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References
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WESTON, P., BARRETT, A. & DINGLE, J. Specific Inhibition of Cartilage Breakdown. Nature 222, 285–286 (1969). https://doi.org/10.1038/222285b0
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DOI: https://doi.org/10.1038/222285b0
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