Abstract
Sparsomycin inhibits protein biosynthesis by inducing the formation of an inert complex between the peptidyl donor substrate and the 50S ribosomal subunit.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Argoudelis, A. D., and Herr, R. R., in Antimicrobial Agents and Chemotherapy (American Society for Microbiology), 780 (1962).
Owen, S. P., Dietz, A., and Camiener, G. W., in Antimicrobial Agents and Chemotherapy (American Society for Microbiology), 772 (1962); Slechta, L., ibid., 326; Slechta, L., in Antibiotics, 1, Mechanism of Action (edit. Gottlieb, D., and Shaw, P. D.), 410 (Springer-Verlag, 1967).
Goldberg, I. H., and Mitsugi, K., Biochem. Biophys. Res. Commun., 23, 453 (1966).
Colombo, B., Felicetti, L., and Baglioni, C., Biochim. Biophys. Acta, 119, 109 (1966).
Goldberg, I. H., and Mitsugi, K., Biochemistry, 6, 383 (1967); Jayaraman, J., and Goldberg, I. H., ibid., 7, 418 (1968).
Vazquez, D., and Monro, R. E., Biochim. Biophys. Acta, 142, 155 (1967).
Lucas-Lenard, J., and Haenni, A. L., Proc. US Nat. Acad. Sci., 59, 554 (1968); Pestka, S., ibid., 61, 726 (1968); Scolnik, E., Tompkins, R., Caskey, T., and Nirenberg, M., ibid., 61, 768 (1968); Trakatellis, A. C., ibid., 59, 854 (1968).
Monro, R. E., and Vazquez, D., J. Mol. Biol., 28, 161 (1967).
Monro, R. E., and Marcker, K. A., J. Mol. Biol., 24, 347 (1967).
Monro, R. E., J. Mol. Biol., 26, 147 (1967).
Monro, R. E., Cerna, J., and Marcker, K. A., Proc. US Nat. Acad. Sci., 61, 1042 (1968).
Maden, B. E. H., Traut, R. R., and Monro, R. E., J. Mol. Biol., 35, 333 (1968).
Hille, M. B., Miller, M. J., Iwosaki, K., and Wahba, A. J., Proc. US Nat. Acad. Sci., 58, 1652 (1967).
Bray, G. A., Anal. Biochem., 1, 279 (1960).
Sanger, F., Brownlee, G. G., and Barrell, B. G., J. Mol. Biol., 13, 373 (1965).
Maden, B. E. H., and Monro, R. E., Europ. J. Biochem. (1968).
Leder, P., and Bursztyn, H., Biochem. Biophys. Res. Commun., 25, 233 (1966).
Ennis, H. L., Mol. Pharmacol., 2, 444 (1966).
Chang, F. M., and Weisblum, B., Biochemistry, 6, 836 (1967).
Vazquez, D., Life Sci., 6, 381 (1967).
Vazquez, D., Life Sci., 6, 845 (1967).
Weissblum, B., and Davies, J., Bact. Rev. (in the press).
Goldberg, I., and Mitsugi, K., Biochemistry, 6, 372 (1967).
Herner, A. E., Cohen, L. B., and Goldberg, I. H., Fed. Proc., 27, 771 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MONRO, R., CELMA, M. & VAZQUEZ, D. Action of Sparsomycin on Ribosome-catalysed Peptidyl Transfer. Nature 222, 356–358 (1969). https://doi.org/10.1038/222356a0
Received:
Issue date:
DOI: https://doi.org/10.1038/222356a0
This article is cited by
-
Modeling Ribosomal Translocation Facilitated by Peptidyl Transferase Antibiotics
Cellular and Molecular Bioengineering (2016)
-
The hybrid state of tRNA binding is an authentic translation elongation intermediate
Nature Structural & Molecular Biology (2006)
-
A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome
Nature (1995)
-
Pharmacokinetics of the antitumor antibiotic n-pentyl-sparsomycin in beagle dogs
Investigational New Drugs (1990)
-
In vivo antitumor activity of sparsomycin and its analogues in eight murine tumor models
Investigational New Drugs (1988)