Abstract
FURST1 has argued that most drugs which retard the growth of human or experimental neoplasms are actual or potential chelating agents. Although the correlation of the two properties is probably often no more than coincidental, the idea of attempting to influence the growth of cells and tumours with chelating agents has been examined2–5. It is an attractive idea because many enzyme systems depend on or contain trace metals.
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References
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CREIGHTON, A., HELLMANN, K. & WHITECROSS, S. Antitumour Activity in a Series of bisDiketopiperazines. Nature 222, 384–385 (1969). https://doi.org/10.1038/222384a0
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DOI: https://doi.org/10.1038/222384a0
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