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Uncoupling and Recoupling of Oxidative Phosphorylation in Brown Adipose Tissue Mitochondria

Abstract

Uncoupling of oxidative phosphorylation, postulated as a means of heat production in the brown adipose tissue of rodents, is brought about in guinea-pigs by the cold stress at birth and by exposing weaned animals to the cold. Ability to recouple in hibernating rodents may be of evolutionary significance.

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CHRISTIANSEN, E., PEDERSEN, J. & GRAV, H. Uncoupling and Recoupling of Oxidative Phosphorylation in Brown Adipose Tissue Mitochondria. Nature 222, 857–860 (1969). https://doi.org/10.1038/222857a0

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