Abstract
RECENT experiments indicate that cells of at least two kinds can cooperate in the antibody response of mice to foreign red blood cells. Thymus and bone marrow cells confer significant antibody responsiveness on lethally irradiated mice when injected together, but not separately1, and it seems probable that it is the bone marrow, and not the thymus, cells that make the antibody2. There is no evidence, however, as to which population dictates the specificity of the response. The discovery that mice can be made specifically hypo-responsive “tolerant”) to sheep red blood cells3 means that this point can be tested.
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References
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PLAYFAIR, J. Specific Tolerance to Sheep Erythrocytes in Mouse Bone Marrow Cells. Nature 222, 882–883 (1969). https://doi.org/10.1038/222882a0
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DOI: https://doi.org/10.1038/222882a0
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