Abstract
The reconstitution of active pyruvate Carboxylase—occurring without protein synthesis and with high efficiency—shows a virtually complete dependence on acetyl-coenzyme A and is inhibited by L-aspartate. The reaction may represent a novel mode of regulating the formation of an active enzyme.
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References
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CAZZULO, J., SUNDARAM, T. & KORNBERG, H. Regulation of Pyruvate Carboxylase Formation from the Apo-enzyme and Biotin in a Thermophilic Bacillus. Nature 223, 1137–1138 (1969). https://doi.org/10.1038/2231137a0
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DOI: https://doi.org/10.1038/2231137a0
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