Abstract
THE recent report by Bremer, Nützenadel and Bickel1 of the use of prepared thin-layer plates of cellulose for screening of plasma for inborn errors of amino-acid metabolism prompts us to report our experience with prepared cellulose layers on aluminium foil (E. Merck, Darmstadt, Germany) for screening of both plasma and urine. Thin-layer chromatography of amino-acids on cellulose is faster, and has greater sensitivity and resolution, than paper chromatography2,3 without sample preparation. Additionally, the flexible aluminium foils can be dipped in the location reagent instead of being sprayed, and appropriate sections cut out for testing with specific reagents.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bremer, H. J., Nützenadel, W., and Bickel, H., Mschr. Kinderheilk., 117, 32 (1969).
Scriver, C. R., Davies, E., and Cullen, A. M., Lancet, ii, 230 (1964).
Efron, M. L., Young, D., Mozer, H. W., and MacCready, R. A., New Engl. J. Med., 270, 1378 (1964).
Woolf, L. I., Gt Ormond St J., 2, 61 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ERSSER, R., SEAKINS, J. Screening for Aminoacidopathies with Prepared Cellulose Layers on Aluminium Foil. Nature 223, 1388 (1969). https://doi.org/10.1038/2231388a0
Received:
Issue date:
DOI: https://doi.org/10.1038/2231388a0
