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Lest I Forget Thee, Glutathione …

Abstract

Glutathione plays many parts in living organisms, and new methods for the oxidation of this tripeptide reveal some of them. This review of the present situation ends with some suggestions for the future.

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References

  1. de Rey-Pailhade, J., CR Acad. Sci., 106, 1683 (1888).

    ADS  Google Scholar 

  2. Hopkins, F. G., Biochem. J., 15, 286 (1921).

    Article  CAS  Google Scholar 

  3. Pirie, N. W., and Pinhey, K. G., J. Biol. Chem., 84, 321 (1929).

    CAS  Google Scholar 

  4. Glutathione (edit. by Colowick, S., et al.) (Academic Press, New York, 1954).

  5. Glutathione (edit. by Crook, E. M.), Biochem. Soc. Symp. No. 17, (Cambridge University Press, 1959).

  6. Knox, W. E., in The Enzymes (edit. by Boyer, P. D., Lardy, H., and Myrback, K.), 2, 253 (Academic Press, New York, 1960).

    Google Scholar 

  7. Kosower, N. S., Vanderhoff, G. A., Kosower, E. M., and Huang, P-k. C., Biochem. Biophys. Res. Commun., 20, 469 (1965).

    Article  CAS  Google Scholar 

  8. Kosower, N. S., Song, K. R., and Kosower, E. M., Biochim. Biophys. Acta, 192, 1 (1969).

    Article  CAS  Google Scholar 

  9. Kosower, N. S., Song, K. R., Kosower, E. M., and Correa, W., Biochim. Biophys. Acta, 192, 8 (1969).

    Article  CAS  Google Scholar 

  10. Huang, P-k. C., and Kosower, E. M., J. Amer. Chem. Soc. 90, 2354, 2362, 2367 (1968).

    Article  CAS  Google Scholar 

  11. Kosower, E. M., Huang, P-k. C., and Tsuji, T., J. Amer. Chem. Soc., 91, 2325 (1969).

    Article  CAS  Google Scholar 

  12. Takahashi, H., Murai, T., and Sasaki, T., Nature, 182, 1675 (1958).

    Article  ADS  CAS  Google Scholar 

  13. Karlin, A., and Bartels, E., Biochim. Biophys. Acta, 126, 525 (1966).

    Article  CAS  Google Scholar 

  14. HuneeusCox, F., Fernandez, H., and Smith, B. H., Biophys. J., 6, 675 (1966).

    Article  CAS  Google Scholar 

  15. Albuquerque, E. X., Sokoll, M. D., Sonesson, B., and Thesleff, S., Europ. J. Pharmacol., 4, 40 (1968).

    Article  CAS  Google Scholar 

  16. Karlin, A., Biochim. Biophys. Acta, 139, 358 (1967).

    Article  CAS  Google Scholar 

  17. Karlin, A., and Winnik, M., Proc. US Nat. Acad. Sci., 60, 668 (1968).

    Article  ADS  CAS  Google Scholar 

  18. Silman, I., and Karlin, A., Science, 164, 1420 (1969).

    Article  ADS  CAS  Google Scholar 

  19. Galun, R., and Margalit, J., Nature, 222, 583 (1969).

    Article  ADS  CAS  Google Scholar 

  20. Galun, R., Avi-Dor, Y., and Bar-Zeev, M., Science, 142, 1674 (1963).

    Article  ADS  CAS  Google Scholar 

  21. Galun, R., and Kindler, S. H., J. Insect Physiol., 14, 1409 (1968).

    Article  CAS  Google Scholar 

  22. Galun, R., and Kindler, S. H., Experientia, 24, 1140 (1968).

    Article  Google Scholar 

  23. Lenhoff, H. M., Science, 161, 434 (1968).

    Article  ADS  CAS  Google Scholar 

  24. Harris, J. W., Exp. Cell. Res., 56, 299 (1969).

    Article  CAS  Google Scholar 

  25. Richmond, D. V., and Somers, E., Biochem. Biophys. Res. Commun., 25, 657 (1966).

    Article  CAS  Google Scholar 

  26. Pluijgers, C. W., Berg, J., Sijpersteijn, A. K., Tempel, A., and Verloop, A., Rec. Trav. Chim., 87, 833 (1968).

    Article  CAS  Google Scholar 

  27. Mazia, D., in The Cell (edit. by Brachet, J., and Mirsky, A.), 3, 250, 355 (Academic Press, 1961).

    Google Scholar 

  28. Harris, J. W., Painter, R. B., and Hohn, G. M., Int. J. Rad. Biol., 15, 289 (1969).

    CAS  Google Scholar 

  29. Harrap, K. R., Jackson, R. C., and Hill, B. T., Biochem. J., 111, 603 (1969).

    Article  CAS  Google Scholar 

  30. Henkin, R. I., and Bradley, D. F., Proc. US Nat. Acad. Sci., 62, 30 (1969).

    Article  ADS  CAS  Google Scholar 

  31. Piomelli, S., and Siniscalco, M., Brit. J. Haematol., 16, 537 (1969).

    Article  CAS  Google Scholar 

  32. Hockwald, R. S., Arnold, J., Clayman, C. B., and Alving, A. S., J. Amer. Med. Assoc., 149, 1568 (1952); Beutler, E., Pharmacol. Rev., 21, 73 (1969).

    Article  CAS  Google Scholar 

  33. Marks, P. A., and Banks, J., Ann. NY Acad. Sci., 123, 198 (1965).

    Article  ADS  CAS  Google Scholar 

Download references

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KOSOWER, E., KOSOWER, N. Lest I Forget Thee, Glutathione …. Nature 224, 117–120 (1969). https://doi.org/10.1038/224117a0

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