Abstract
IN the peripheral nervous system sympathomimetic amines can be divided into two classes1: those that act directly and those that act indirectly, according to whether or not their action can be demonstrated in the absence of functional noradrenergic innervation2. In terms of this classification, the amphetamines mostly act indirectly and a similar hypothesis about their mode of action in the central nervous system has frequently been held. Vane, however, proposed that amphetamine might act on cerebral “tryptamine receptors”3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Burn, J. H., in Adrenergic Mechanisms (edit. by Vane, J. R., Wolstenholme, G. E. W., and O'Connor, M.), 320 (Churchill, London, 1960).
Fleckenstein, A., and Burn, J. H., Brit. J. Pharmacol., 8, 69 (1953).
Vane, J. R., in Adrenergic Mechanisms, 356 (1960).
Stein, L., Fed. Proc., 23, 836 (1964).
Doepfner, W., and Cerletti, A., Intern. Arch. Allergy, 12, 89 (1958).
Doepfner, W., Experientia, 18, 256 (1962).
Spector, S., Sjoerdsma, A., and Udenfriend, S., J. Pharmacol., 147, 86 (1965).
Olds, M. E., and Olds, J., J. Comp. Neurol., 20, 259 (1963).
Marley, E., and Morse, W. H., Brit. J. Pharmacol., 31, 367 (1967).
Poschel, B. P. H., and Ninteman, F. W., Life Sci., 5, 11 (1966).
Spector, S., Pharmacol. Rev., 18, 599 (1966).
Dewhurst, W. G., and Marley, E., Brit. J. Pharmacol., 5, 705 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CROW, T. Mode of Enhancement of Self Stimulation in Rats by Methamphetamine. Nature 224, 709–710 (1969). https://doi.org/10.1038/224709a0
Received:
Revised:
Issue date:
DOI: https://doi.org/10.1038/224709a0
This article is cited by
-
5-HT1A agonists and dopamine: the effects of 8-OH-DPAT and buspirone on brain-stimulation reward
Journal of Neural Transmission (1991)
-
The relationship between amphetamine antagonism and depletion of brain catecholamines by alpha-methyl-p-tyrosine in rats
Naunyn-Schmiedeberg's Archives of Pharmacology (1978)
-
Effects of catecholamine-depleting drugs and amphetamine on self-stimulation of brain following various 6-hydroxydopamine treatments
Psychopharmacologia (1974)
-
Intracranial self-stimulation in rats as a function of various stimulus parameters
Psychopharmacologia (1974)