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Mode of Enhancement of Self Stimulation in Rats by Methamphetamine

Abstract

IN the peripheral nervous system sympathomimetic amines can be divided into two classes1: those that act directly and those that act indirectly, according to whether or not their action can be demonstrated in the absence of functional noradrenergic innervation2. In terms of this classification, the amphetamines mostly act indirectly and a similar hypothesis about their mode of action in the central nervous system has frequently been held. Vane, however, proposed that amphetamine might act on cerebral “tryptamine receptors”3.

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CROW, T. Mode of Enhancement of Self Stimulation in Rats by Methamphetamine. Nature 224, 709–710 (1969). https://doi.org/10.1038/224709a0

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