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Transesterification by Peptidyl Transferase

Abstract

Peptidyl transferase, the enzyme which catalyses formation of peptide bonds, can be stimulated by CCA, the 3′-terminus of tRNA, to catalyse also a transesterification reaction involving nucleophilic attack of Met-tRNAfMet by ethanol to yield fMet-ethyl ester.

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SCOLNICK, E., MILMAN, G., ROSMAN, M. et al. Transesterification by Peptidyl Transferase. Nature 225, 152–154 (1970). https://doi.org/10.1038/225152a0

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