Abstract
Peptidyl transferase, the enzyme which catalyses formation of peptide bonds, can be stimulated by CCA, the 3′-terminus of tRNA, to catalyse also a transesterification reaction involving nucleophilic attack of Met-tRNAfMet by ethanol to yield fMet-ethyl ester.
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References
Maden, B. E. H., and Monro, R. E., Europ. J. Biochem., 6, 309 (1968).
Rychlik, I., Cerna, J., Chladek, S., Zemlicka, J., and Haladoya, Z., J. Mol. Biol, 43, 13 (1969).
Caskey, C. T., Tompkins, R., Scolnick, E., Caryk, T., and Nirenberg, M., Science, 162, 135 (1968).
Milman, G., Goldstein, J., Scolnick, E., and Caskey, T., Proc. US Nat. Acad. Sci., 63, 183 (1969).
Monro, R. E., and Vasquez, D., J. Mol. Biol., 28, 161 (1967).
Pestka, S., and Nirenberg, M. W., J. Mol. Biol., 21, 145 (1966).
Leder, P., Singer, M. F., and Brimacombe, R. L. C., Biochemistry, 4, 1501 (1965).
Kellogg, D. A., Doctor, B. P., Loebel, J. E., and Nirenberg, M. W., Proc. US Nat. Acad. Sci., 55, 912 (1966).
Erbe, R. W., Nau, M. W., and Leder, P., J. Mol. Biol., 39, 441 (1969).
Watson, J. D., Bull. Soc. Chim. Biol., 46, 1399 (1964).
Takanami, M., Proc. US Nat. Acad. Sci., 52, 1271 (1964).
Waller, J. P., Erdos, T., Lemoine, F., Guttmann, S., and Sandrin, E., Biochim. Biophys. Acta, 119, 566 (1966).
Neumann, H., Shashova, Y., Sheehan, J., and Rich, A., Proc. US Nat. Acad. Sci., 61, 1207 (1968).
Bernhard, S. A. The Structure and Function of Enzymes, 177 (Benjamin, New York, 1968).
Bender, M. L., and Kezdy, F. J., Ann. Rev. Biochem., 34, 49 (1965).
Scolnick, E., Tompkins, R., Caskey, T., and Nirenberg, M., Proc. US Nat. Acad. Sci., 61, 765 (1968).
Caskey, T., Scolnick, E., Tompkins, R., Goldstein, J., and Milman, G., Cold Spring Harbor Symp. Quant. Biol (in the press).
Scolnick, E., Milman, G., Goldstein, J., Tompkins, R., and Caskey, T., Fed. Proc., 28, 598 (1968).
Scolnick, E., and Caskey, T., Proc. US Nat. Acad. Sci. (in the press).
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SCOLNICK, E., MILMAN, G., ROSMAN, M. et al. Transesterification by Peptidyl Transferase. Nature 225, 152–154 (1970). https://doi.org/10.1038/225152a0
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DOI: https://doi.org/10.1038/225152a0
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