Abstract
Riley and Seal1 suggested that butylated hydroxyanisole (BHA) might be a carcinogen in view of the observation in guinea-pigs of pseudopods of deep epithelium of skin penetrating the basement membrane after surface application of BHA (20 per cent w/w in lanolin) daily for 6 weeks. Similar effects were reported with two analogues of BHA (3-hydroxyanisole and 4-hydroxyanisole) and the phenomenon, termed microinvasion, has recently been discussed in greater detail2–4. A marked resemblance was alleged to have been found between this lesion and the microinvasive process seen in premalignant hamster cheek pouch epithelium which had been painted with the carcinogen 7,12-dimethylbenz(α)anthracene (DMBA) and in possible premalignant human oral mucosa. Furthermore, it was pointed out that one of the earliest morphological lesions seen in human skin tumours is microinvasion.
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GRASSO, P., ROSTRON, C. Microinvasion of Epidermis caused by Substituted Anisoles. Nature 225, 188–189 (1970). https://doi.org/10.1038/225188a0
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DOI: https://doi.org/10.1038/225188a0
