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Rheumatoid Anti Gm Factors with Specificity for the pFc′ Subfragment of Human Immunoglobulin G

Nature volume 225, pages 855–857 (1970)Cite this article

Abstract

THE rheumatoid factors are anti-γ-globulin antibodies directed against heavy chain determinants in the Fc region of immunoglobulin G (IgG). Although quantitative differences seem to exist, each of the four subclasses of IgG is able to interact with suitable preparations of rheumatoid factor1,2. In addition, Gm genetic markers are involved in certain rheumatoid factor reactions and the delineations of several new Gm markers have been performed with anti Gm antibodies from patients with rheumatoid arthritis, for example, Gm(a), (x), (b) and (g)3. It is now more common, however, to use anti Gm antibodies from normal individuals or heteroantisera for Gm typing3.

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Authors and Affiliations

  1. Research Institute of Immunology and Rheumatology, Rikshospitalet University Hospital, Oslo

    J. B. NATVIG

  2. Institute of Child Health, London

    M. W. TURNER

Authors
  1. J. B. NATVIG
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  2. M. W. TURNER
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NATVIG, J., TURNER, M. Rheumatoid Anti Gm Factors with Specificity for the pFc′ Subfragment of Human Immunoglobulin G. Nature 225, 855–857 (1970). https://doi.org/10.1038/225855a0

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