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Reductant-activation of Inorganic Pyrophosphatase : an ATP-conserving Mechanism in Anaerobic Bacteria

Nature volume 226, pages 1250–1251 (1970)Cite this article

Abstract

INORGANIC pyrophosphatases are key enzymes in the biosynthesis of proteins, nucleic acids and polysaccharides the polymerization of which takes place by reaction sequences in which a nucleoside triphosphate (NTP) reacts with a monomer (R) or monomer phosphate to give an “active” monomer (here simplified to NMPR) plus inorganic pyrophosphate (PPi): Polymerization takes place by transfer of the active monomer to the polymer chain and release of nucleotide Because the equilibrium of reaction (1) generally lies to the left, the formation of active monomer is “pulled” by inorganic pyrophosphatases

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References

  1. Gordon, J. J., Biochem. J., 66, 50 (1957).

    Article  CAS  Google Scholar 

  2. Seal, U. S., and Binkley, F., J. Biol. Chem., 228, 193 (1957).

    CAS  PubMed  Google Scholar 

  3. D'Eustachio, A. J., Knight, E., and Hardy, R. W. F., J. Bact., 90, 288 (1965).

    CAS  PubMed  Google Scholar 

  4. Peck, H. D., Bact. Rev., 26, 67 (1962).

    CAS  Google Scholar 

  5. Akagi, J. M., and Campbell, L. L., J. Bact., 86, 563 (1963).

    CAS  PubMed  Google Scholar 

  6. Baliga, B. S., Vartag, H. G., and Jagganathan, V., J. Sci. Ind. Res., 20C, 33 (1961).

    Google Scholar 

  7. Postgate, J. R., J. Gen. Microbiol., 57, 293 (1969).

    Article  CAS  Google Scholar 

  8. Moses, V., J. Gen. Microbiol., 13, 235 (1955).

    Article  CAS  Google Scholar 

  9. Taussky, H., and Shoor, E., J. Biol. Chem., 202, 675 (1953).

    CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. ARC Unit of Nitrogen Fixation, University of Sussex, Brighton, BN1 9QJ, Sussex

    D. WARE & J. R. POSTGATE

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  1. D. WARE
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  2. J. R. POSTGATE
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WARE, D., POSTGATE, J. Reductant-activation of Inorganic Pyrophosphatase : an ATP-conserving Mechanism in Anaerobic Bacteria. Nature 226, 1250–1251 (1970). https://doi.org/10.1038/2261250a0

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