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Biologically Active Antibodies to Histamine

Nature volume 226, page 360 (1970)Cite this article

Abstract

IT has been known for some time that peptides, aminoacids and proteins containing the substituents COOH and NH2 can be linked together by the use of water soluble basic carbodiimides1. Goodfriend et al.2 showed that linking the polypeptides of bradykinin and angiotensin with rabbit serum albumin (RSA) by the use of carbodiimides produced a complex which was highly antigenic. Subsequently Davis et al.3 showed that the antibodies induced by the bradykinin–RSA complex were protective against the biological effects of bradykinin, and Oken et al.4 obtained similar results with angiotensin. So far the use of carbodiimides has been confined to protein and peptide syntheses.

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References

  1. Sheehan, J. C., and Hlavka, J. J., J. Org. Chem., 21, 439 (1956).

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  2. Goodfriend, T. L., Levine, L., and Fasman, G., Science, 144, 1344 (1964).

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  3. Davis, T. R. A., and Goodfriend, T. L., Amer. J. Physiol., 217, 73 (1969).

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  4. Oken, D. E., and Biber, T. U. L., Amer. J. Physiol., 214, 791 (1968).

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Authors and Affiliations

  1. Life Sciences Division, Arthur D. Little, Inc., Cambridge, Massachusetts

    THOMAS R. A. DAVIS & KATHLEEN M. MEADE

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  1. THOMAS R. A. DAVIS
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  2. KATHLEEN M. MEADE
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DAVIS, T., MEADE, K. Biologically Active Antibodies to Histamine. Nature 226, 360 (1970). https://doi.org/10.1038/226360a0

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