Abstract
RECENT epidemiological studies reveal a highly significant correlation between infectious mononucleosis and the development of serum antibodies to EB virus (EBV)1,2. It has been suggested that these findings indicate that EBV is probably the causative agent in infectious mononucleosis. An alternative hypothesis is that EBV may merely be a poorly immunogenic, non-aetiological “passenger” virus that is activated non-specifically during the proliferation of lymphoreticular cells in infectious mononucleosis with subsequent appearance of detectable EBV antibodies3–8. The second hypothesis may be tested in part by studying EBV antibody responses that occur in infectious lymphocytosis, a mild communicable paediatric illness of unknown aetiology in which elevated absolute and relative lymphocyte counts develop, usually without specific signs or symptoms9.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Henle, G., Henle, W., and Diehl, V., Proc. US Nat. Acad. Sci., 59, 94 (1968).
Evans, A. S., Neiderman, J. C., and McCollum, R. W., New Engl. J. Med., 279, 1121 (1968).
Chessin, L. N., Glade, P. R., Kasel, J. A., Moses, H. L., Herberman, R. B., and Hirshaut, Y., Ann. Int. Med., 69, 333 (1968).
Editorial, New Engl. J. Med., 279, 1168 (1968).
Glade, P. R., Hirshaut, Y., Douglas, S. D., and Hirschhorn, K., Lancet, ii, 1273 (1968).
Glade, P. R., Hirschhorn, K., and Douglas, S. D., Lancet, i, 1049 (1969).
Editorial, Lancet, ii, 887 (1969).
Hirshaut, Y., Glade, P., Moses, H., Manaker, R., and Chessin, L., Amer. J. Med., 47, 520 (1969).
Smith, C. H., Amer. J. Dis. Child., 62, 231 (1941).
Bell, J. A., Huebner, R. J., Rosen, L., Rowe, W. P., Cole, R. M., Mastrota, F. M., Floyd, T. M., Chanock, R. M., and Shvedoff, R. A., Amer. J. Hyg., 74, 267 (1961).
Kaariainen, L., Klemola, E., and Paloheimo, J., Brit. Med. J., i, 1270 (1966).
Henle, G., and Henle, W., J. Bact., 91, 1248 (1966).
Gerber, P., Walsh, J. H., Rosenblum, E. N., and Purcell, R. H., Lancet, i, 593 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BLACKLOW, N., KAPIKIAN, A. Serological Studies with EB Virus in Infectious Lymphocytosis. Nature 226, 647 (1970). https://doi.org/10.1038/226647a0
Received:
Issue date:
DOI: https://doi.org/10.1038/226647a0
