Abstract
IT has been argued that most of the evolutionary changes observed in homologous proteins are the result of chance fixation of selectively neutral mutations1,2. This hypothesis would be clarified by a more detailed analysis of observed patterns of amino-acid substitutions in related proteins than has been attempted previously3.
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References
King, J. L., and Jukes, T. H., Science, 164, 788 (1969).
Arnheim, N., and Taylor, C. E., Nature, 223, 900 (1969).
Epstein, C. J., Nature, 210, 25 (1966).
Dayhoff, M. O., and Eck, R. V., Atlas of Protein Sequence and Structure 1967–1968, National Biomedical Research Foundation, Silver Springs, 1968).
Zimmerman, S. M., Eliezer, N., and Simha, R., J. Theor. Biol., 21, 170 (1968).
Whitfield, H. J., Jr., Martin, R. G., and Ames, B., J. Mol. Biol., 21, 335 (1966).
Fisher, R. A., The Genetical Theory of Natural Selection (Dover, New York, 1958).
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LANKS, K., KITCHIN, F. Conservative Mutations in Homologous Proteins. Nature 226, 753–754 (1970). https://doi.org/10.1038/226753a0
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DOI: https://doi.org/10.1038/226753a0
