Abstract
α-AMANITIN, a bicyclic polypeptide from the toadstool Amanita phalloides1, is known specifically to inhibit the DNA-dependent RNA polymerase of mammalian cells by interaction with the enzyme rather than with the DNA template2,3. No influence of the toxin on the replication of a number of DNA or RNA-containing viruses has been found so far (ref. 4 and personal communication from L. Philipson). Actinomycin, which reacts with the DNA template and so impairs the DNA-dependent RNA polymerase reaction, depresses the multiplication of influenza viruses but does not interfere with the replication of most of the other RNA-containing viruses5–7. Because the mode of action of this antibiotic on the synthesis of influenza viruses is still obscure, we extended our studies to the action of α-amanitin on the multiplication of this virus group.
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References
Wieland, Th., Science, 159, 946 (1968).
Seifart, K. H., and Sekeris, C. E., Z. Naturforsch., 24 b, 1538 (1969).
Jacob, S. T., Sajdel, E. M., and Munro, H. N., Nature, 225, 60 (1969).
Fiume, L., LaPlaca, M., and Portolani, M., Sperimentale, 116, 15 (1966).
Barry, R. D., Ives, D. R., and Cruickshank, J. G., Nature, 194, 1139 (1962).
Rott, R., and Scholtissek, C., Z. Naturforsch., 19 b, 316 (1964).
White, D. O., Day, H. M., Batchelder, E. J., Cheyne, I. M., and Wansbrough, A. J., Virology, 25, 289 (1965).
Scholtissek, C., and Rott, R., Virology, 40, 989 (1970).
Scholtissek, C., and Rott, R., J. Gen. Virol., 5, 283 (1969).
Scholtissek, C., Becht, H., and McPherson, I., J. Gen. Virol., 8, 11 (1970).
Scholtissek, C., Biochim. Biophys. Acta, 179, 389 (1969).
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ROTT, R., SCHOLTISSEK, C. Specific Inhibition of Influenza Replication by α-Amanitin. Nature 228, 56 (1970). https://doi.org/10.1038/228056a0
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DOI: https://doi.org/10.1038/228056a0
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