Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Reactivity of Inbred Mouse Sera with Antisera to the Variable Region of Light Chains

Abstract

The presence of common antigenic determinants in a panel of human and mouse Bence–Jones proteins and a human myeloma protein has facilitated a study of the genetic control of immunoglobulin synthesis in mice.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Edelman, G. M., and Gall, W. E., Ann. Rev. Biochem., 38, 415 (1969).

    Article  CAS  Google Scholar 

  2. Milstein, C., Nature, 209, 370 (1966).

    Article  ADS  CAS  Google Scholar 

  3. Baglioni, C., Alescio-Zonta, L., Cioli, D., and Carbonara, A., Science, 152, 1517 (1966).

    Article  ADS  CAS  Google Scholar 

  4. Ein, D., Proc. US Nat. Acad. Sci., 60, 982 (1968).

    Article  ADS  CAS  Google Scholar 

  5. Milstein, C., Nature, 216, 330 (1967).

    Article  ADS  CAS  Google Scholar 

  6. Langer, B., Steimetz-Kayne, M., and Hilschmann, N. Z., Z. Physiol. Chem., 349, 945 (1968).

    CAS  Google Scholar 

  7. Gray, W., Dreyer, W., and Hood, C., Science, 155, 465 (1967).

    Article  ADS  CAS  Google Scholar 

  8. Melchers, F., Biochemistry, 8, 938 (1969).

    Article  CAS  Google Scholar 

  9. Ruffilli, A., and Baglioni, C., J. Immunol., 104, 1247 (1970).

    CAS  PubMed  Google Scholar 

  10. Baglioni, C., and Cioli, D., J. Exp. Med., 124, 307 (1966).

    Article  CAS  Google Scholar 

  11. Cioli, D., and Baglioni, C., J. Mol. Biol., 15, 385 (1966).

    Article  CAS  Google Scholar 

  12. Robbins, J. B., Haimovitch, J., and Sela, M., Immunochemistry, 4, 11 (1967).

    Article  CAS  Google Scholar 

  13. Fleischman, J. B., Porter, R. R., and Press, E. M., Biochem. J., 88, 220 (1963).

    Article  CAS  Google Scholar 

  14. Smithies, O., Cold Spring Harbor Symp. Quant. Biol., 32, 161 (1967).

    Article  Google Scholar 

  15. Cohn, M., in Nucleic Acids in Immunology (edit. by Plescia, O. J., and Braun, W.,) 671 (Springer-Verlag, New York, 1968).

    Book  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

RUFFILLI, A., BAGLIONI, C. Reactivity of Inbred Mouse Sera with Antisera to the Variable Region of Light Chains. Nature 228, 1048–1050 (1970). https://doi.org/10.1038/2281048a0

Download citation

  • Received:

  • Issue date:

  • DOI: https://doi.org/10.1038/2281048a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing