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Fibrin Proteolysis in the Monkey Uterine Cavity: Variations with and without IUD

Nature volume 228, pages 1097–1099 (1970)Cite this article

Abstract

THE uterine tissues of several mammalian species are an abundant source of plasminogen activator1. Human menstrual discharge is known to contain high concentrations of plasminogen activator and plasmin but insignificant amounts of fibrinogen and plasminogen2. Plasmin, the product of plasminogen activation, proteolytically degrades fibrin and fibrinogen preferentially to other substrates; so a likely physiologic role of plasminogen activator in the uterus would be that of maintaining menstrual blood in a fluid state.

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Author notes

  1. S. T. SHAW JUN. & D. L. MOYER

    Present address: Department of Obstetrics and Gynecology, Los Angeles County—University of Southern California Medical center, Los Angles, California

Authors and Affiliations

  1. Department of Pathology, Los Angeles County Harbor General Hospital, Torrance, California

    S. T. SHAW JUN., R. W. CIHAK & D. L. MOYER

Authors
  1. S. T. SHAW JUN.
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  2. R. W. CIHAK
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  3. D. L. MOYER
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SHAW, S., CIHAK, R. & MOYER, D. Fibrin Proteolysis in the Monkey Uterine Cavity: Variations with and without IUD. Nature 228, 1097–1099 (1970). https://doi.org/10.1038/2281097a0

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  • DOI: https://doi.org/10.1038/2281097a0

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