Abstract
THE presence of prostaglandins in the hypothalamus of the dog1 raises the interesting possibility that they are important in regulating the release of pituitary hormones. This possibility is strengthened by the demonstration that prostaglandin E1 (PGE1) acts on the anterior pituitary in vitro, activating adenyl cyclase and increasing the concentration of adenosine 3′5′-cyclic monophosphate (3′5′-AMP)2. Theophylline also increases the concentration of 3′5′-AMP in the anterior pituitary, by inhibiting cyclic nucleotide phosphodiesterase3, and has been shown to stimulate the release of growth hormone in vitro4. If the increase in 3′5′-AMP in the tissue mediates the stimulation of release by theophylline, prostaglandin E1 should also stimulate release. The effect of PGE1 on the release of growth hormone has therefore been determined using the incubation system and radioimmunoassay which I have described before5.
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SCHOFIELD, J. Prostaglandin E1 and the Release of Growth Hormone in Vitro. Nature 228, 179–180 (1970). https://doi.org/10.1038/228179a0
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DOI: https://doi.org/10.1038/228179a0
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