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Nature of Acquired Resistance to Filarial Infection in Albino Rats

Abstract

ALBINO rats infected with the filarial parasite Litomosoides carinii acquire resistance in 3–4 months as judged by the absence of microfilariae in the peripheral blood1. The rats at this stage have latent infection revealed by the presence of adult worms and microfilariae in the pleural cavity. In vivo studies on the factors involved suggested that circulating antibodies of these rats which include a homologous anaphylactic8 and reaginic3 types do not play a significant part4. Available data, however, indicated that the acquired resistance was related to a systemic cell-mediated immunity3 that seems to be most active in the pleural cavity4, where the adult worms and microfilariae were present. We report here the results of a study of the acquired resistance.

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BAGAI, R., SUBRAHMANYAM, D. Nature of Acquired Resistance to Filarial Infection in Albino Rats. Nature 228, 682–683 (1970). https://doi.org/10.1038/228682a0

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