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Sex Difference in the Number of Adipose Cells from Genetically Obese Rats

Nature volume 231, page 50 (1971)Cite this article

Abstract

IT is well known that there is no increase in the number of adipose cells in many kinds of experimental obesity. In genetically obese mice, obob obese hyperglycaemic1,2 or yellow obese3 syndromes as well as in hypothalamic obesities produced by aurothioglucose in mice4 or stereotaxic lesions in rats5, there is only an enlargement of the adipose cells. The same results are obtained in rats made obese by a high fat diet6. There is only one known exception to this rule: obesity induced by a high fat diet in female mice7, in which the number of cells is increased by a factor of 2.5. Because male animals were used in all experiments except the last, the question arises whether there may be a sex difference in the adipose tissue development in obese animals.

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  1. Laboratory of Biology and Human Nutrition, CNAM, 292 Rue Saint Martin, 75, Paris, 3

    DANIEL LEMONNIER

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  1. DANIEL LEMONNIER
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LEMONNIER, D. Sex Difference in the Number of Adipose Cells from Genetically Obese Rats. Nature 231, 50 (1971). https://doi.org/10.1038/231050a0

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