Abstract
Bassett, Pawluk and Becker1 reported that they had observed marked bone production in the femora of dogs 3 weeks after insertion into the bone of implants which produced a few µA of direct current through platinum–iridium electrodes. This work was repeated by O'Connor and colleagues2, who were able to report “general confirmation” of Bassett's results, and who found difficulty in assessing the degree of bone growth. We have tried to reproduce the results reported by Bassett1 in rabbits, and to develop a precise method of assessing the degree of bone growth.
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References
Bassett, C. A. L., Pawluk, R. J., and Becker, R. O., Nature, 204, 652 (1964).
O'Connor, B. T., Charlton, H. M., Currey, J. D., Kirby, D. R. S., and Woods, C., Nature, 222, 162 (1969).
Charkes, N. D., Sklaroff, D. M., and Young, I., Amer. J. Roentgenol., 96, 647 (1966).
Vaughan, J. M., The Physiology of Bone (Clarendon Press, Oxford, 1970).
Lavine, L. S., and Lustrin, I., Nature, 224, 1112 (1969).
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HAMBURY, H., WATSON, J., SIVYER, A. et al. Effect of Microamp Electrical Currents on Bone in vivo and its Measurement using Strontium-85 Uptake. Nature 231, 190–192 (1971). https://doi.org/10.1038/231190a0
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DOI: https://doi.org/10.1038/231190a0
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