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Identification of an Unusual Y Chromosome in YY Mosaicism by Quinacrine Fluorescence

Nature volume 231, pages 388–389 (1971)Cite this article

Abstract

WE have recently had the opportunity to study the rare association of mixed gonadal dysgenesis in a female child and X/XY/XYY mosaicism in karyotypes from blood and fibroblast cultures. The quinacrine fluorescence technique1,2 permitted us to identify the Y chromosome, which in this case is unusually large and not identifiable for certain by other means. So far the value of the quinacrine fluorescence technique has been primarily in screening for extra Y chromosomes and for karyotyping. Now it seems that this new technique may supplant or substitute autoradiographic analysis3.

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References

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Author notes

  1. MIRIAM G. WILSON & JOSEPH W. TOWNER

    Present address: Department of Pediatrics, 1200 North State Street, Los Angeles, California, 90033

Authors and Affiliations

  1. Department of Pediatrics, Los Angeles County—University of Southern California Medical Center, Los Angeles, California, 90033

    JOSEPH W. TOWNER

  2. Southern California Permanente Medical Group, Kaiser Foundation Hospital, Panorama City, California

    JACK LIPSHIN & ARTHUR FLEISHER

Authors
  1. MIRIAM G. WILSON
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  2. JOSEPH W. TOWNER
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  3. JACK LIPSHIN
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  4. ARTHUR FLEISHER
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WILSON, M., TOWNER, J., LIPSHIN, J. et al. Identification of an Unusual Y Chromosome in YY Mosaicism by Quinacrine Fluorescence. Nature 231, 388–389 (1971). https://doi.org/10.1038/231388a0

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