Abstract
SIMIAN virus 40 (SV40) is a natural infection of rhesus and some other Asiatic macaques1 and has no known natural host in the United States. It is therefore difficult to account for our finding of antibodies neutralizing SV40 in the sera of some elderly persons in the United States who do not have a history of immunization with any vaccine prepared in rhesus kidney cultures. The only recognized exposure of the US population to this virus occurred when poliovirus and adenovirus vaccines prepared in rhesus kidney cultures and administered to a large number of people were later found to have been contaminated with SV40 (ref. 1). The chief exposure occurred between 1955 and 1961 through the use of Salk vaccine, and it is known that subcutaneous administration of SV40 gives a long-lasting antibody response2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Sweet, B. H., and Hilleman, M. R., Proc. Soc. Exp. Biol. Med., 105, 420 (1960).
Gerber, P., Proc. Soc. Exp. Biol. Med., 125, 1284 (1967).
Shah, K. V., Proc. Soc. Exp. Biol. Med., 121, 303 (1966).
Shah, K. V., J. Nat. Cancer Inst., 42, 139 (1969).
Ozer, H. L., Takemoto, K. K., Kirschstein, R. L., and Axelrod, D., Virology, 3 (1), 17 (1969).
Shah, K. V., Goverdhan, M. K., and Ozer, H. L., Amer. J. Epidemiol., 93, 291 (1971).
Shah, K. V., Palma, L. D., and Murphy, G. P., J. Surg. Oncol., 3 (in the press).
CDC, USPHS, Polio Surveillance Reports, Report No. 248, 5 (1961).
Gerber, P., Hottle, G. A., and Grubbs, R. E., Proc. Soc. Exp. Biol. Med., 108, 205 (1961).
Zu Rhein, G., Prog. Med. Virol., 11, 185 (1969).
Vernon, M. L., Fuccillo, D. A., and Hamilton, R., Fed. Proc., 29, No. 229 (1970).
Koprowski, H., Barbanti-Brodano, G., and Katz, M., Nature, 225, 1045 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SHAH, K., OZER, H., POND, H. et al. SV40 Neutralizing Antibodies in Sera of US Residents without History of Polio Immunization. Nature 231, 448–449 (1971). https://doi.org/10.1038/231448a0
Received:
Revised:
Issue date:
DOI: https://doi.org/10.1038/231448a0
This article is cited by
-
Simian virus 40 in humans
Infectious Agents and Cancer (2007)
-
BK virus infection, replication, and diseases in pediatric kidney transplantation
Pediatric Nephrology (2007)
-
Papova virus-like particles in a nigral type of creutzfeldt-jakob disease
Journal of Neurology (1976)
