Abstract
REPORTS on the fluorescence-sensitive binding of d-LSD (d-lysergic acid diethylamide), 1-LSD and their 2-bromo derivatives to calf thymus DNA1, and on changes induced in DNA circular dichroism by LDS-25 (ref. 2), have led to the belief that it is the intercalation of the drug in DNA that causes the chromosomal damage3–6 and abnormalities in human offspring7 that have been associated with LSD. Our studies of circular dichroism, however, have failed to show that LSD has any effect on DNA conformation.
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References
Yielding, K. L., and Sterglanz, H., Proc. Soc. Exp. Biol. Med., 128, 1096 (1968).
Wagner, T., Nature, 222, 1170 (1969).
Alexander, G. J., Miles, B. E., Gold, G. M., and Alexander, R. B., Science, 157, 461 (1967).
Irwin, S., and Egozcue, J., Science, 157, 312 (1967).
Cohen, M. M., and Mukerjee, A. B., Nature, 219, 1972 (1968).
Cohen, M. M., Hirschhorn, K., and Frosch, W. A., New Engl. J. Med., 277, 1043 (1967).
Hsu, L. Y., Strauss, L., and Hirschhorn, K., J. Amer. Med. Assoc., 211, 987 (1970).
Brahms, J., and Mommaerts, W. F. H. M., J. Mol Biol., 10, 73 (1964).
Waring, M. J., J. Mol. Biol., 13, 269 (1965).
LePecq, J. B., and Paoletti, C., J. Mol. Biol., 27, 87 (1967).
Aktipis, S., and Martz, W. M., Biochem. Biophys. Res. Commun., 39, 307 (1970).
Tinoco, jun., I., Adv. Chem. Phys., 4, 113 (1962).
Papirmeister, B., and Wolpert, J. S., Biochem. Biophys. Res. Commun., 39, 307 (1970).
Smart, R. G., and Bateman, K., Canad. Med. Assoc. J., 99, 805 (1968).
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BRADY, A., BRADY, E. & BOUCEK, F. Optical Activity of LSD–DNA Mixtures. Nature 232, 189–190 (1971). https://doi.org/10.1038/232189a0
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DOI: https://doi.org/10.1038/232189a0
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